Drawing on a review of 60 innovation centers in the U.S., Onil Bhattacharyya, M.D., a 2015–16 Canadian Harkness Fellow, together with the Commonwealth Fund’s David Blumenthal, M.D., and Eric Schneider, M.D., explore in a recent NEJM Catalyst article how health systems can organize themselves to redesign health care services, develop digital health tools, or create new models of care.